Key points GLP-1 is a hormone that increases insulin release and prevents the release of too much glucagon, helping manage blood glucose levels in individuals with type 2 diabetes GLP-1 receptor agonists, such as liraglutide and semaglutide, effectively reduce blood glucose levels Semaglutide is more effective than liraglutide at reducing blood sugar levels Tirzepatide is a newer GLP-1 receptor agonist that also mimics the actions of another hormone called GIP, which can also reduce blood sugar levels A randomised controlled trial showed that tirzepatide led to more significant blood sugar reductions than semaglutide across three doses Tirzepatide may be more effective than semaglutide at higher doses, but this needs further investigation Liraglutide and semaglutide are available in the UK and the US, while tirzepatide is only available in the US but is likely to be approved in the UK soon

These side effects are real and deserve clinical attention, and they should be managed by a physician experienced in obesity medicine
You will also find that your clothes fit better and look sharper on your body
Frequently Asked Questions Can I use a general peptide calculator for semaglutide
doi: 10.1007/s00125-011-2232-3 55 PangJFengJNLingWJinT
Including these benefits in the microsimulation model would have made the GLP-1 drugs look a bit more cost-effective