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Ben-Arieh SV, Zimerman B, Smorodinsky NI, Yaacubovicz M, Schechter C, Bacik I, et al

Consistent with this, MTP siRNA reduced basal respiration by 15% (OCR: 143.6 6.9 vs

Maiorino M, et al

Since imine bonds hydrolyze under acidic conditions, the gatekeeper molecules such as PEG, polyglycerol, peptide, and carbohydrate could be severed from the surface at low pH thus opening the pores and releasing the loaded guest molecules 131,132,133

2013;8(6):E68846

These resistant analogues have a prolonged metabolic stability in vivo and improved biological activity, which is of great interest in the treatment of type 2 diabetes and/or obesity