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The role of gut microbiota in depression: an analysis of the gut-brain axis

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Estrogen Exposure and Adipose-Driven Hormonal Modulation Because adipose tissue produces estrogen via aromatase, reductions in visceral fat can lower peripheral estrogen levels in some individuals

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-20.2% vs -13.7% at 72 weeks

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doi: 10.3389/fphar.2025.1675552 Received 29 July 2025 Accepted 28 August 2025 Published 11 September 2025 Volume 16 - 2025 Edited by Claudia Manca, University of Cagliari, Italy Reviewed by Basveshwar Gawali, Washington University in St

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