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Human data: Human data comprises pharmacokinetic/pharmacodynamic study in volunteers and a completed Phase II trial for postoperative ileus (NCT00672074)
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Cell Death Disco
doi:10.1001/jamainternmed.2024.4661
Luminal glucose represents the most potent secretagogue for incretin hormone release in vivo , an effect mainly mediated by the sodium-dependent glucose transporter, SGLT1 (SLC5A1) ( Along the lines of GLP-1 analogs and DPP-4 inhibitors, various agonists of GPR40 and GPR120 have been developed and proven effective in ameliorating glycemic control in animal trials ( Several other transporters and receptors, such as the facilitative glucose transporter (GLUT2), are thought to play a role in incretin secretion, however, their contribution to luminal compound sensing remains unclear
Presented for research literature review only Swamy-Mruthinti S et al
