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That growth hormone prompts the liver to produce IGF-1, which supports protein synthesis, lean mass, and body recomposition over time
Tirzepatide may also worsen diabetic retinopathy, particularly in patients who are also using insulin, so monitoring is advised
Patients with these conditions require careful evaluation by their provider before initiating therapy, as they may be at increased the risk for gastrointestinal adverse effects or complications
The distribution at each timepoint of interest suggests uptitration to the 1.5 mg dosage formulation among Italian incident users, with dosage increase to the 3.0 mg or 4.5 mg formulations (which were not available in Italy) in France, 16% and 5% respectively