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Tirzepatide and semaglutide represent two distinct approaches to GLP-1 therapy: tirzepatide activates both GLP-1 and GIP receptors, while semaglutide targets only the GLP-1 pathway
For instance, siBec1@PPN nanoparticles deliver siRNA against Beclin-1 to silence autophagy, reverse treatment resistance, and potentiate combined anticancer therapies [71]
Others may find semaglutide easier to tolerate
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