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Traditional proteomics-based methods, such as N-terminomics 37,38,39 and proteomic identification of protease cleavage sites 40 , are well suited for global analyses of protease activity but can be low throughput and may lack the sensitivity to detect low-frequency, yet biologically perturbative, off-target cleavage events

10.1016/j.ejphar.2014.07.051 143 TenbrockL.WolfJ.BonevaS.SchlechtA.AgostiniH.WieghoferP.et al (2022)

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Oral GLP-1 options The shift from injectable to oral GLP-1 formulations may also change the coverage calculus