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The effects on humans remain uncertain, though they cant yet be dismissed
Im now maintaining a weight I havent been at since I was 18 years old normal weight , not overweight
Its research profile makes it especially relevant for studies focused on metabolic flexibility, mitochondrial energy output, exercise-related signaling, cardiometabolic models, fatty acid utilization, and cellular energy demand
The lowest FDA-approved dose (0.25 mg/week) is designed for tolerance-building, not weight reduction
A groundbreaking 2014 study tracked over 78,000 diabetes patients across several years to see which treatments had the biggest impact on their health when compared to non-diabetic participants
Top-line outcomes at the 48-week primary endpoint, by dose: Notable Phase 2 finding particularly relevant to the 10mg vial: the 1mg/week cohort still produced 8.7% mean weight loss over 48 weeks, clinically meaningful activity even at sub-therapeutic doses relative to the 12mg maximum
