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Rodents overexpressing USP22 or lncRNA PART1 were well resistant to I/R-induced oxidative stress and cardiac injury, which may be partly attributed to the elevated GSH content in the myocardium [251, 252]
Clinical studies have reported that the GSH content in erythrocytes of patients with T2DM is reduced [18,19,20]
Turkovic et al., 2004)
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However, other methods (such as injection) can be considered more effective due to direct delivery
Antioxidants 12, 123
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