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However, native GLP-1 has low stability in vivo and is inactivated by the enzyme DPP-4 [34].Two strategies exist for overcoming this problem: first, the development of GLP-1 receptor agonists (GLP-1RAs) that activate GLP-1 receptors similarly to native GLP-1

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Clin Biochem 44:364367 Pache M, Ochs J, Genth E, Mierau R, Kube T, Flammer J (2003) Increased plasma endothelin-1 levels in fibromyalgia syndrome

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