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Mechanistically, the KDM8-mediated PKM2 nuclear translocation results in the transcriptional activation of glycolytic program, including GLUT1, HK2, PKM2, LDHA, etc.) and downregulation of genes for pyruvate dehydrogenase complex (PDHA1 and PDHB1) to reduce the direction of pyruvate to mitochondria
The carnitine exists in two stereoisomeric forms, D-carnitine and L-carnitine, but only the latter is biologically active
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Hadley & Hruby 1993), gdzie potwierdzono jej aktywno melanogeniczn u ludzi, ale te dwa nieoczekiwane efekty: indukowane erekcje i nudnoci
1E, F), making it difficult to extricate the other phenotypes potentially caused by the loss of GSH
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