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It is not best suited for severe osteoarthritis, advanced cartilage loss, major joint deformity, complete tendon rupture, fracture, or injuries requiring surgical evaluation

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While standard GLP-1s can sometimes cause lethargy due to reduced caloric intake, Tesofensine actively increases metabolic rate and often improves patient energy levels and focus

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Minimum two to four weeks often required before judging effectiveness for chronic conditions, with some injuries needing six or more weeks to show meaningful response