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Torekov, S
This is linked to weight rebound
Exendin-4, liraglutide and semaglutide can directly or indirectly stimulate POMC neurons in the ARC, while indirectly inhibiting NPY/AgRP neurons via presynaptic GABAergic neurons [82-84]
Remember, while semaglutide can be a powerful tool, it is one part of a larger puzzle that includes healthy lifestyle choices and ongoing medical guidance
Oral semaglutide (Rybelsus) requires specific administration instructions: it must be taken on an empty stomach before the first food, beverage, or other oral medications of the day, with no more than 4 ounces of plain water, and patients must wait at least 30 minutes before eating, drinking, or taking other medications
Liraglutide has a half-life of around 13 hours and semaglutide, about 165 hours , which is equivalent to approximately a week and explains the weekly application
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