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It has been proposed that the circulating peptide could access the brain via the ARC and exert its anorectic actions through indirect activation of pro-opiomelanocortin (POMC) neurons in the hypothalamus and through the blocking of fasting ghrelin levels

By infusing the nutrients intravenously, we bypass the gastrointestinal (GI) system where the acidic environment of the stomach, difficulty of intestinal absorption, and liver metabolism may lead to as little as 20-30% absorption of oral supplements

Although their purposes are similar, their mechanisms, benefits, and usage differ

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Hafeez points out that these drugs have been used for diabetic patients for years