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A landmark discovery in 1995 revealed the first nuclear gene mutation causing mitochondrial respiratory chain deficiency in humans: a mutation in the nuclear-encoded flavoprotein subunit gene of succinate dehydrogenase led to complex II deficiency in two sisters with Leigh syndrome

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Specifically, those with plasma homocysteine levels greater than 14 mol/L had nearly double the risk of developing Alzheimer's disease (71)

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Both Ozempic and insulin are injectable medications used in diabetes management, but they are quite functionally different and are used for distinct purposes