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335 Additionally, lactateHCAR1 signaling in tumor cells activates the 14-3-3STAT3 axis, promoting CCL2/CCL7 production and recruitment of CCR2 PMN-MDSCs, which suppress T cells via ARG1 and ROS, thereby limiting PD-1 blockade efficacy
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An informative article observed that almost onethird of patients receiving glutathione injections experienced side effects such as liver dysfunction, anaphylaxis, and kidney damage, highlighting the lack of standard dosing and the need for safer alternatives
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