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Ghrelin levels drop in the hour after a glucose load or a meal, with the extent of the postprandial suppression being proportional to caloric intake
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Using as a model pituitary GH-secreting rat GH3 cells, the authors showed that disrupting the FLNA/SSTR2 interaction, receptor stability after prolonged agonist stimulation was strongly compromised
And that's what they needed, right, to, to achieve that
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