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sitagliptin Sitagliptin Trade Name: Januvia Drug Class: oral hypoglycemics Mechanism of Action: An inhibitor of dipeptidyl peptidase-4 (DPP-4), a protease that degrades the incretin GLP-1 Incretins are hormones released from the GI tract in response to nutrient ingestion Incretins potentiate glucose-stimulated insulin secretion from beta cells in the pancreas As a result of inhibiting DPP-4, increased or prolonged GLP-1 levels are able to potentiate the secretion of insulin by the pancreas The effect produced by DPP-4 inhibitors is dependent on endogenous GLP-1 levels, and produce a modest effect on GLP-1 activity compared to giving GLP-1 receptor agonists (hence DPP-4 inhibitors do not have the same impact to produce weight loss as GLP-1 agonists)
By the time appetite returns with force at week three, the physiological cascade is already underway: gastric emptying has accelerated, insulin sensitivity has declined, and NEAT has dropped by an average of 200300 calories per day according to metabolic ward studies on GLP-1 discontinuation
The recommended duration of Semaglutide GLP-1 treatment is typically determined by the prescribing healthcare provider
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Retrieved from Forootan, M., Bagheri, N., & Darvishi, M
