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Exposure to sugars induces rapid GLP-1 secretion from T1R3-sensitive cells, following a dose-dependent pattern where higher stimulus concentrations lead to greater secretionan effect blocked by GLP-1 receptor antagonists (61, 67)

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Clinical trials require participants to follow a reduced-calorie diet and increase physical activity, and the weight loss numbers reflect that combination

Neuropsychiatric safety: suicidal ideation and mood disorders Regulatory authorities have recently focused on potential neuropsychiatric adverse eventsincluding suicidal ideation, depression, and anxietyassociated with GLP-1 RAs

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Pellegrino and her husband, Roberto, have three children, Dante, Giovanni and Sophia