Gastrointestinal side effects represent the most common adverse reactions to GLP-1 medications, with frequencies varying by agent but often affecting 20-40% of patients according to product information
doi: 10.1016/S0140-6736(23)01185-6
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A clinical study involving 564 adults (BMI 30-40 kg/m2, without T2DM) found that compared with orlistat (3120 mg, weight loss of 4.1 kg), LIR (subcutaneous administration of 1.2 mg/d, 1.8 mg/d, 2.4 mg/d or 3 mg/d) had an average weight loss of 4.8-7.2 kg, the two-year extended experiment of which also showed similar results (88, 89)
Do not massage the injection site, as this can disperse the peptide too quickly or cause irritation
The question is whether enough experts and officials ultimately agree that GLP-1s will offer a shortcut equivalent to substances like diuretics, which are pills that cause the kidneys to put extra salt and water into urine