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The other non-canonical effects of the v-ATPase that are not readily attributable to its proton-pumping activity include membrane fusion, pH sensing, amino-acid-induced activation of mTORC1, and scaffolding for protein-protein interaction 42,54

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Inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), and leaky gut syndrome are some of the intestinal pathologies that can be caused by endotoxin exposure