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Endogenously, GLP-1 is secreted by intestinal L cells in response to food, and has multiple roles: enhancing insulin secretion (in a glucose-dependent way), reducing glucagon secretion, slowing gastric emptying, increasing feelings of fullness/satiety, and improving glucose disposal in peripheral tissues

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Short supply of drug used for Type 2 diabetes At a glance Guernsey pharmacies facing supply issues for Semaglutide, used to help manage Type 2 diabetes It is used by about 350 people in the island Supply issues may not be resolved "until at least mid-2024", UK says Published Pharmacies in Guernsey have said they are in "very short supply" of a drug used to help manage Type 2 diabetes