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The phase 3 TRIUMPH-4 data showed these rates at 9 mg and 12 mg doses respectively: Nausea: 38.1% and 43.2% (vs 10.7% placebo) Diarrhea: 34.7% and 33.1% (vs 13.4% placebo) Constipation: 21.8% and 25.0% (vs 8.7% placebo) Vomiting: 20.4% and 20.9% (vs placebo) These numbers are higher than cagrilintide monotherapy across the board
Proc Natl Acad Sci USA (2015) 112:1187680
Because Ipamorelin is a highly selective, third-generation peptide, it does not cause the extreme hunger or cortisol spikes associated with older therapies like GHRP-6
This effect is particularly relevant to addiction, where cue-triggered craving often initiates relapse even after extended abstinence
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