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Activation of MC4R is associated with the observed effects on libido, arousal, and appetite suppression

And medicine's answer to this is those are just really general, general symptoms

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Aripiprazole caused initially fatigue, muscular spasms of jaw, and slurring of speech at the dose of 5 mg/day

Exclusion criteria: Non-RCTs (cohort, casecontrol, cross-sectional studies, case reports)