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The leap from "complementary mechanisms in animals" to "effective and safe synergy in humans" has not been made by the evidence
The short answer is that for most people, B12 injections given in a medical setting have a strong safety record
Since one of the significant symptoms of a B12 deficiency is anemia, it stands to reason that those that raise their levels of B12 will feel more energetic and perky
documentation that informed consent occurred and what it covered