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Researchers have linked higher IGF-1 levels to greater bone mineral density in older female subjects

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Unlike fulllength hGH, AOD9604 does not meaningfully elevate IGF1 levels or worsen glucose tolerance, making its tolerability indistinguishable from placebo in human trials [2] [3]

The phase 2 trial found that starting at 2mg rather than 4mg significantly reduced nausea rates during escalation, validating the conservative titration approach

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Author contributions LS and TG conceived the research