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While all Cbl initially enters the bloodstream bound to TCN2, only about 2030% of the total blood cobalamin is transported by TCN2 and is thus in the biologically active form, with the remaining 7080% bound to Hc [89]

The balance between these two forms is a critical indicator of cellular oxidative stress

(4) Teichman SL, Neale A, Lawrence B, Gagnon C, Castaigne JP, Frohman LA

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In this NADH form it is an electron carrier, with the electrons serving as stored potential energy

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