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It plays a role in extracellular matrix remodeling through several mechanisms: stimulation of collagen I, III, and IV synthesis
In chronic kidney disease, urinary and plasma biomarkers of fibrosis, together with functional MRI approaches, represent promising tools, although further validation is required
Koch, M
Clinically, high-dose corticosteroid therapy (oral, intravenous, and periocular injections) significantly improves patients visual acuity, while immunosuppressants like methotrexate reduce the recurrence rate of ON [170]
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