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Dysaesthesia, an abnormal sensory condition, occurred in more than 12% of patients at the highest dose, consistent with earlier retatrutide studies
The Adrenals and the Thyroid Adrenal function and thyroid function are both significantly impacted by HPA activity
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Both medications commonly cause gastrointestinal side effects (nausea, diarrhoea, abdominal discomfort) which may be more pronounced when combined
The challenge is to get these results into clinical practice, to get the drug used by the people who will benefit from it, who will live longer without dialysis, without heart attacks, without strokes, if they take this drug. Novo Nordisk will need to seek regulatory approval for semaglutide to be used to treat those with chronic kidney disease
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