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Most common side effects were gastrointestinal, with 24.5% of participants in the phase 2 obesity trial discontinuing efinopegdutide 10 mg due to AE however when the same dose was used with gradual escalation at the MASLD trial (starting dose 2.4 mg for 4 weeks, then 5 mg for 4 weeks and then 10 mg), only 5.6% of participants discontinued the medication due to AE

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Research dosing (clinical settings only): Self-administration of kisspeptin outside clinical supervision is not recommended due to the need for precise weight-based dosing and IV/SubQ technique

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Tyrosine The amino acid tyrosine is a precursor of the thyroid hormone thyroxine and several neurotransmitters (dopamine, norepinephrine)

Serum creatinine and blood urea nitrogen (BUN) assay Serum creatinine was determined using the Point creatinine assay (#C7548) according to the manufacturers directions