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The 8mg dose produced the highest fat mass reduction in clinical trials (26.1%), while the 12mg dose showed comparable efficacy with slightly higher side effect rates

2024;22(6):125564 e18

Pharmaceutics 15 , 778 (2023)

Biochem Eng J

Shows for the first time that telomere shortening to a critical length in mammals results in loss of histone and DNA methylation at mammalian telomeres and subtelomeres, concomitant with increased histone acetylation