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Desrosiers TA, Siega-Riz AM, Mosley BS, Meyer RE, National Birth Defects Prevention S

Blood in stool while taking tirzepatide (Mounjaro, Zepbound) is not a recognized side effect in FDA prescribing information, but warrants immediate medical evaluation

These mechanisms are studied in cell-culture and animal models, not in humans

Protocols are typically 36 months in duration, with reassessment of labs and body composition at regular intervals

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Circulating insulin-like growth factor 1(IGF-1) progressively decreases with age and is strongly associated with reduced muscle protein synthesis, mitochondrial biogenesis, and functional capacity ( Figure 1 )