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10.1001/jama.287.23.3116 85

TMAO is associated with mortality: Impact of modestly impaired renal function

It binds the GHRH receptor on pituitary cells and works through the Gs protein and cyclic AMP pathway, as outlined in a review of growth hormone secretagogues

234 Additionally, GLP-1 can reduce blood glucose production by delaying gastric emptying and decreasing appetite, which also contributes to overall blood glucose control

These therapies are generally well tolerated when monitored, but possible effects include water retention or swelling, joint or nerve discomfort, irritation at the injection site, and shifts in blood sugar if growth hormone runs too high

doi: 10.1093/advances/nmz064 118 ShanksJRamchandraR