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They even had a small but statistically significant reduction in depressive symptoms

Patients should feel empowered to ask questions about their treatment plan, including why a particular GLP-1 medication was chosen, what specific monitoring is recommended, and when to seek urgent medical attention

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Koneczny, I., Cossins, J., Waters, P., Beeson, D

Because the incidence of AEs was greatest during dose escalation, the disparity in total years of exposure between the two trials could potentially dilute the reported rate of AEs in PIONEER 3 compared with PIONEER 12

For someone who cares about energy levels, exercise capacity, or just feeling good day to day, that tradeoff demands some serious scrutiny and consideration