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246 To address this issue, ongoing trials such as MUSIC-HFrEF (NCT04703842) and MUSIC-HFpEF (NCT06061549) are exploring the use of patented titration techniques to optimize dosage, aiming to achieve therapeutic efficacy while minimizing adverse effects

Theres a sense that if theyre not killing people, we should have them available. There have always been complaints that the FDA is too slow, Zuckerman says, but historically, one of the reasons why lots of countries look to our drug regulatory system and our safety data to say if a drug is safe is because our system works really well

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Sodium hydroxide, ethanol and glutaraldehyde were purchased from Sinopharm Chemical Reagent Co., Ltd (Shanghai, China)

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