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It is also possible that the effect of these drugs may have been limited because previous studies have reported that GLP-1 and GIP receptors are downregulated by glucose toxicity 27

To evaluate the association of obesity and metastasis, progression of the tumor to metastasis of Py230 and EO771 grafts were studied by Bousquenaud M et al., who showed that tumors in obese mice grew faster, was less vascularized, more hypoxic, enriched with CD11b + Ly6G + neutrophils in an ovariectomized C57BL/6 J female mice

Also, by the energy of 9.20, 9.10, and 8.90 kcal/mol, dioscin, silymarin, and silibinin interacted with the binding site of TOP2- , respectively

Teeranachaideekul V, Parichatikanond W, Junyaprasert VB, Morakul B