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During molecular dynamic simulations with GLP-1 bound, the N-terminal helix was oriented vertically (black and blue arrows), whereas in the apo-form the ECD N-terminal helix was more dynamic and experienced both open and closed conformations (this is analogous to the suggested ECD dynamics for the glucagon receptor)

What is the purity

It never gained FDA approval in the U.S

The growing use of GLP-1 drugs in clinical practice makes these findings particularly significant

They start with movement