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Higher mean age and baseline SBP, greater use of anti-hypertensive medications, longer T2D duration, and reduction in insulin daily dose might have contributed to explain the difference observed in the impact of weight loss on SBP reduction in these trials, although direct GLP-1R- and GIP-R-mediated effects could also be considered [77]

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When injected into osteoarthritic joints, they are shown to modulate inflammation, promote cartilage repair, and delay OA progression

Semaglutide targets only the GLP-1 receptor and achieved 14.9% mean weight loss at 68 weeks in the STEP 1 trial