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This non-linear pattern suggests that the body may develop some tolerance to the GI effects at higher maintenance doses, particularly after a proper titration schedule

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Bottom row: 24-2 Humphrey visual fields grey scale and pattern deviation from 1-year follow-up

(2) Cytokines, such as tumor necrosis factor-alpha (TNF) and IL-6, which can contribute to inflammation and apoptosis in ACM, further exacerbating cardiac dysfunction (104)