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Association between MTHFR gene polymorphisms and the risk of autism spectrum disorders: a meta-analysis

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Proc Biochem 40:34743479

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167,168 In hepatocytes, elevated lipid load and insulin resistance increase mitochondrial -oxidation activity, accompanied by electron leakage and respiratory chain disruption, resulting in substantial ROS production, which exacerbates lipid peroxidation, autophagic dysfunction, and pyroptosis