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Transdermal estradiol, delivered through patches or gels rather than oral tablets, bypasses the liver entirely, avoiding the first-pass hepatic metabolism that oral estrogen undergoes and that is associated with increased clotting factor production and thrombotic risk
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They also found that ROSE-010 was most effective in patients with constipation-dominant IBS (IBS-C) and mixed IBS, with significantly less pain relief observed in patients with diarrhea-dominant or unspecified IBS [62]
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Considering the antioxidant potencies of phenolic compounds and more generally of secondary metabolites, the connection of GSTs with secondary metabolism may be interesting from a pharmacological perspective
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