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Lifestyle Factors : Identify habits like smoking or high alcohol intake that could compromise healing or elevate risk

Neurology 64 (9), 156372

Adaptive design clinical trials: current status by disease and trial phase in various perspectives

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For example, emerging protein targets like IL-4, IL-10, IL-15, IL-17, IL-18, IL-23, interleukin-1 receptor-associated kinase (IRAK)-4 have been revealed to have a strong implication with innate and adaptive immune response in RA ( Protein Targets for Treatment of Rheumatoid Arthritis Currently, many agents aiming at various protein targets have been explored and tested to ease the progression of RA, and some agents have been used in the clinic to treat RA patients ( Table 1 )