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Even on the current addressable market for obesity only, we see scope for better-than-expected growth in the US alone, as the penetration rate in US adults is still small at 1.5%
Currently, the only treatment that has been shown to be effective in MASLD is a weight loss of 710%, which improves histologic fibrosis and steatosis 7
On the other hand, Kupffer cell-derived IL-10 can restrict the injury by limiting iNOS induction [100, 101] and at later time points by promoting pro-regenerative gene expression in hepatocytes surrounding the area of necrosis [102]
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Clinical trials with existing GLP-1 receptor agonists have borne out these benefits, demonstrating significant reductions in HbA1c, weight, and often insulin requirements
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