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Notably, 58.6% of retatrutide-treated participants on the 12 mg dose achieved at least 25% weight loss at 68 weeks, a threshold that was vanishingly rare before this drug class existed

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Another challenge, researchers say, is that symptoms of nutrient deficiency including fatigue, nausea, and irritability can overlap with the common side effects of GLP-1 medications, making problems harder to spot early

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