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Although the insulinotropic effect of GIP is diminished in patients with type 2 diabetes, studies have found that GIP receptor agonists can induce a degree of weight loss and, when used in combination with GLP-1, can produce synergistic effects, enhancing blood glucose reduction and weight loss
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A total of 41% of the study volunteers had nausea, which varied in severity: Mild: 21% Moderate: 3% Severe: 15% Further, about 56% of the study volunteers complained of stretching and yawning, which also varied in severity: Mild: 36% Moderate: 13% Severe: 8% Other recorded side effects included in this review were flushing, increased or decreased appetite, and drowsiness
Am J Clin Dermatol 9:1531 Donath MY, Shoelson SE (2011) Type 2 diabetes as an inflammatory disease
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Compounded semaglutide and tirzepatide are legal with a prescription, clinician oversight, and a state-licensed pharmacy
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