Duan Y, Li F, Li Y, Tang Y, Kong X, Feng Z, Anthony TG, Watford M, Hou Y, Wu G, Yin Y
The uptake by the liver and kidneys is relatively low
This clinical approach delivers measurable benefits that set the brand apart from typical supplement retailers
A study in the Journal of Neurology, Neurosurgery, and Psychiatry found it helped patients with diabetic neuropathy
This upregulation promotes increased cell growth, healthy cell proliferation, healing effects, and cell migration, particularly keratinocytes and endothelial cells
Reported applications include NNMT enzyme inhibition assays measuring 1-methylnicotinamide formation or S-adenosylhomocysteine release, intracellular target-engagement assays in differentiated 3T3-L1 adipocytes where 5-Amino-1MQ reduced intracellular 1-methylnicotinamide with an EC near 2.3 M (Neelakantan et al., Biochem Pharmacol, 2018), membrane permeability and Caco-2 transport characterisation, methyltransferase selectivity panels covering COMT, DNMT1 and PRMT3, and rodent studies of NNMT inhibition in adipose tissue and liver following the antisense knockdown work of Kraus and colleagues (Nature, 2014)