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Hallmark pathological features include degeneration of DA neurons in the substantia nigra and the presence of Lewy bodies (LBs) within surviving neurons (Sulzer et al., 2017)

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A recent study demonstrated that GLP-1 enhances preingestive satiety through hypothalamic circuits in both mice and humans, with GLP-1R-expressing neurons in the dorsomedial hypothalamus (DMH) emerging as key candidates for encoding this satiety signal [24]

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