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3.2 BA signaling in lipid metabolism NAFLD is marked by significant lipid accumulation in the liver and BAs exert a profound effect on lipid metabolism mainly via FXR signaling

Peptide 20, a GIPR/GLP-1R/GCGR triagonist (phase 1 clinical trials completed) 18,19,20 with balanced potency at the three receptors, is evolved from a GLP-1R/GCGR dual agonist 21 through iterative sequence refinement and modification (Supplementary Fig

Regional variation limits applications of healthy gut microbiome reference ranges and disease models