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The incidence of diarrhoea was significantly higher in the metformin group at weeks 4 ( p = 0.003) and 8 ( p = 0.01), but no longer at week 16

According to data reported in the New England Journal of Medicine [2], higher doses achieved up to 17.5% weight reduction at 24 weeks and over 24% at 48 weeks, alongside consistent HbA1c lowering

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2003 Jan;11(1):23-9

Two types of medications for ulcers and gastric reflux proton-pump inhibitors, such as omeprazole (Prilosec) and lansoprazole (Prevacid), and H2 blockers like cimetidine (Tagamet), famotidine (Pepcid), and ranitidine (Zantac) inhibit the release of stomach acid necessary to free dietary vitamin B12