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More research is needed to understand the mechanism by which females may experience more weight reduction in these trials, said lead author Dr Luis-Emilio Garca from Eli Lilly and Company, Indianapolis, USA.

Nine percent of participants were also found to have regained their entire body weight

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First, although all included studies were high-quality large-scale RCTs, their small number restricted our ability to explain sources of heterogeneity through subgroup analyses